Dynamic Image Prediction Using Principal Component and Multi-Channel Singular Spectral Analysis: A Feasibility Study

Abstract

Respiratory motion induces the limit in delivery accuracy due to the lack of the consideration of the anatomy motion in the treatment planning. Therefore, image-guided radiation therapy (IGRT) system plays an essential role in respiratory motion management and real-time tumor tracking in external beam radiation therapy. The objective of this research is the prediction of dynamic time-series images considering the motion and the deformation of the tumor and to compensate the delay that occurs between the motion of the tumor and the beam delivery. For this, we propose a prediction algorithm for dynamic time-series images. Prediction is performed using principal component analysis (PCA) and multi-channel singular spectral analysis (MSSA). Using PCA, the motion can be denoted as a vector function and it can be estimated by its principal component which is the linear combination of eigen vectors corresponding to the largest eigen values. Time-series set of 320-detector-row CT images from lung cancer patient and kilovolt (kV) fluoroscopic images from a moving phantom were used for the evaluation of the algorithm, and both image sets were successfully predicted by the proposed algorithm. The accuracy of prediction was quite high, more than 0.999 for CT images, whereas 0.995 for kV fluoroscopic images in cross-correlation coefficient value. This algorithm for image prediction makes it possible to predict the tumor im-ages over the next breathing period with significant accuracy.