Isolation and characterization of 2,4,5-trimethoxybenzaldehyde and 1-(2,4,5-trimethoxyphenyl)-ethanone from Pachypodanthium staudtii, and their general toxicity towards brine shrimps

Abstract

The 1D and 2D NMR analyses, notably, 1H, 13C PENDANT, HMQC, HMBC and NOESY, were carried out on two benzene derivatives, 2,4,5-trimethoxybenzaldehyde and 1-(2,4,5-trimethoxyphenyl)-ethanone, isolated from the dichloromethane extract of the stem bark of Pachypodanthium staudtii. The general toxicity of these compounds (LC50 = 32.6 and 80.5 μg/mL, respectively) was determined by the brine shrimp lethality bioassay.