Effectiveness of administration haramounting leaf (Rhodomyrtus tomentosa) as antioxidant in preventing the damage pancreas mice (Mus musculus L.) after exposure of electric cigarette smoke

Abstract

Cigarette Smoke is contain free radical was cause diabetes. Chemicals used to prevent or slow down free radical damage are antioxidants. Antioxidants in haramounting play a role to neutralize, free radicals. The study aims to determine the effectiveness of haramounting leaf extract (Rhomodytrus tomentosa) as an antioxidant to histological pancreas mice (Mus musculus L.) exposed to electric cigarette. For research Methods, First, thirty six mice collected randomly and were asssigned six group including: control +, control -, Haramounting exract 100mg/kg for 28 days and 45 days, and Given Haramounting exract 200mg/kg exposured to smoke cigarette for 28 days and 45 days. For research started, first, preparation samples and extracts, exposure to cigarette smoke and extracticing, animal test surgery, preparation of a pancreatic surgery histology and analysis of data from weight loss, blood sugar levels and all sections of histology pancreatic organs of Mice. For reserach weight was weighed on the first day of treatment and weighed once a week on a regular basis. P3 is a haramounting group with a dosage of 200 mg / kg bw and exposure to smoke for 28 days only has a higher mean body weight compared to other groups. However, based on statistical tests, there is no real difference. Based on the test results obtained Ko (+) (exposed to cigarette smoke, without the extract) was not significantly different. This is because Ko (+) exposed to cigarette smoke without haramounting leaves extract as an antioxidant. Rhomodyrtus tomentosa have great potential as a natural antioxidant source. Haramonting leaf (Rhodomyrtus tomentosa) can prevent pancreatic damage seen from result of blood glucose value. Seeing the potential of haramonting leaf extract (Rhodomyrtus tomentosa) is good enough it is necessary to do further research for the development of haramounting leaf extract as an herbal medicine for the community.