Abstract
Diosmin (DSN) is found mainly in citrus fruits, and has potent antioxidant effects. This study aimed to evaluate pharmacokinetics of diosmetin-7-glucoside-γ-cyclodextrin (DIOSG-CD) inclusion complex. The area under the curve values from AUC0-24 of DIOSG-CD, prepared by reacting DSN and naringinase with γ-CD, were approximately 800-fold higher than those of DSN following their administration in Sprague-Dawley rats.
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Moriwaki, M., Kito, K., Nakagawa, R., Kapoor, M. P., Matsumiya, Y., Fukuhara, T., … Kuroiwa, Y. (2023). Increased bioavailability of diosmetin-7-glucoside-γ-cyclodextrin inclusion complex compared with diosmin in Sprague-Dawley rats. Bioscience, Biotechnology and Biochemistry, 87(7), 771–776. https://doi.org/10.1093/bbb/zbad051
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