A merger of organocatalysis and visible light photoredox catalysis performed in flow allowed access to a wide range of functionalizedN-aryl-substituted tetrahydroisoquinolines (THIQs) in a formal C-H oxidation/Mannich reaction. Strecker type functionalization and copper-catalyzed alkynylation of severalN-aryl-substituted THIQs were also successfully performed in flow, giving valuable products with high efficiencies. The use of custom-made porous polymeric type microreactors proved to be crucial regarding the C-H oxidation step and overall reaction performance.
CITATION STYLE
Filipović, A., Džambaski, Z., Vasiljević-Radović, D., & Bondžić, B. P. (2021). Visible light promoted photoredox C(sp3)-H bond functionalization of tetrahydroisoquinolines in flow. Organic and Biomolecular Chemistry, 19(12), 2668–2675. https://doi.org/10.1039/d0ob02582h
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