Journal Article

Synthesis of paenipeptin C′ analogues employing solution-phase CLipPA chemistry

Organic and Biomolecular Chemistry (2020) 18(23) 4381-4385
DOI: 10.1039/d0ob00950d
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Abstract

We herein report the synthesis of analogues of the antimicrobial lipopeptide, paenipeptin C′, by installing varying lipid moieties using thiol-ene CLipPA (Cysteine Lipidation on a Peptide or Amino Acid) chemistry. Biological evaluation against both Gram-negative and Gram-positive strains indicated that several analogues possessed potent broad-spectrum antimicrobial activity. This journal is

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APA

Tong, J. T. W., Kavianinia, I., Ferguson, S. A., Cook, G. M., Harris, P. W. R., & Brimble, M. A. (2020). Synthesis of paenipeptin C′ analogues employing solution-phase CLipPA chemistry. Organic and Biomolecular Chemistry, 18(23), 4381–4385. https://doi.org/10.1039/d0ob00950d

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