Novel ether derivatives of alkyl piperidines as potential sigma / 5HT2 antipsychotic agents

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Abstract

A series of novel cinnamyl and propargyl ether derivatives of alkyl piperidines which show high affinity for sigma and 5HT2 receptors are described. The ligands exhibit high selectivities for these receptors over D2 as well as good activity in vivo in anti-mescaline scratch assay. © 1994.

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Christos, T. E., Cain, G. A., Johnson, A. L., Schmidt, W. K., & Tam, S. W. (1994). Novel ether derivatives of alkyl piperidines as potential sigma / 5HT2 antipsychotic agents. Bioorganic and Medicinal Chemistry Letters, 4(19), 2347–2352. https://doi.org/10.1016/0960-894X(94)85038-0

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