A study of alkylation regioselectivity of 5-substituted tetrazoles with chloroacetamides

Abstract

Alkylation of 5-aryltetrazoles with N-arylchloroacetamides commonly proceeds regioselectively at 2 position of the tetrazole ring. The ratio of 1,5-and 2,5-regioisomers depends on the nature of a substituents in the benzene ring of the N-arylchloroacetamide and position of a substituent in the aryltetrazole aryl group. Features of 1H NMR spectra of the synthesized compounds are discussed. © Pleiades Publishing, Ltd., 2010.