Synthesis of chiral sulfonamide/Schiff base ligands

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Abstract

We report a facile two step synthesis of chiral ligands for bonding to transition metals. The ligands are easily prepared from trans, 1,2- diaminocyclohexane by reaction with sulfonyl chlorides to give amino- sulfonamide compounds. These intermediates are then condensed with salicylaldehyde derivatives to provide sulfonamide/Schiff base compounds which represent a new class of chiral ligands.

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Balsells, J., Mejorado, L., Phillips, M., Ortega, F., Aguirre, G., Somanathan, R., & Walsh, P. J. (1998). Synthesis of chiral sulfonamide/Schiff base ligands. Tetrahedron Asymmetry, 9(23), 4135–4142. https://doi.org/10.1016/S0957-4166(98)00431-5

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