Further isolation of coumarin from Angelica pubescens Maxim f. Shan et Yuan.

Abstract

The roots and rhizomes of Angelica pubescens Maxim f. Shan et Yuan were extd. with 80% ethanol for 3 times. After removing the solvent under reduced pressure, the concd. material was suspended in H2O and extd. successively with CHCl3, EtOAc and n-BuOH. 9 Coumarin compds. were isolated and they were identified as columbianedin, osthol, bergapten , isoimperatorin, angelidiol (I), nodakenetin (II), marmesinin (III), columbianin (IV) and meranzin hydrate (V). Among them compd. I was a new natural product and compds. II-V were isolated for the first time from this plant. [on SciFinder(R)]