A standardized, extensible framework for optimizing classification improves marker-gene taxonomic assignments

doi:10.7287/peerj.preprints.49v1

Journal article

A standardized, extensible framework for optimizing classification improves marker-gene taxonomic assignments

Bokulich N, Rideout J, Kopylova E, Bolyen E, Patnode J, Ellett Z, McDonald D, Wolfe B, Maurice C, Dutton R, Turnbaugh P, Knight R, Caporaso J ...see all

PeerJ PrePrints, vol. 3 (2015) p. e934v2

32
Readers
Mendeley users who have this article in their library.
N/A
Citations
Citations of this article.
N/A
Views
ScienceDirect users who have downloaded this article.

Abstract

States of America 10 11 12 13 ABSTRACT 14 Manual therapy has long been a component of physical rehabilitation programs, 15 especially to treat those in pain. The mechanisms of manual therapy, however, are not fully 16 understood, and it has been suggested that its pain modulatory effects are of neurophysiological 17 origin, and may be mediated by the descending modulatory circuit. Therefore, the purpose of this 18 review is to examine the neurophysiological response of different types of manual therapy, in 19 order to better understand the neurophysiological mechanisms behind each therapy's analgesic 20 effects. It is concluded that different forms of manual therapy elicit analgesic effects via different 21 mechanisms. Additionally, future avenues of mechanistic research pertaining to manual therapy 22 are discussed. 23 24 PeerJ PrePrints | https://dx.doi.org/10.7287/peerj.preprints.996v2 | CC-BY 4.0 Open Access | rec: 5 Jun 2015, publ: 5 Jun 2015 PrePrints NEUROPHYSIOLOGY OF MANUAL THERAPY 2 Introduction 25