Synthesis of pyrazolines and isoxazoles as potential antimicrobial agents

Abstract

m,m'-Bis-(p-acetophenylaminosulphonyl)-benzophenone 1 on condensation with various araldehydes yielded chalcones 2a-p which on cyclization with phenyl hydrazine and hydroxylamine hydrochloride furnished the corresponding m,m'-bis- (5-aryl-1-phenyl-pyrazolin-3-yl-p-phenylaminosulphonyI)-benzophenones 3a-p and m,m'-bis (5-arylisoxazol-3-yl-p-phenylaminosulphonyl)-benzophenones 4a-p. The structure of the compounds have been confirmed from elemental analyses, IR, 1H PMR and Mass spectral data. All the products have been evaluated for their in vitro growth inhibitory activity against different microbes.