Abstract
(2S)-indoline-2-carboxylic acid, an intermediate used in the synthesis of perindopril, was prepd. by resoln. of racemic indoline-2-carboxylic acid by reaction with (R)-a-methylbenzylamine. In an example, (2S)-indoline-2-carboxylic acid was obtained with enantiomeric purity > 99.5 %. [on SciFinder (R)]
Author supplied keywords
- 3886-69-9 ((aR)-a-Methylbenzenemethanamine) Role:
- 605646-65-9P Role: RCT (Reactant)
- 7647-01-0 (Hydrochloric acid) Role: RGT (Reagent)
- 78348-24-0 Role: CPS (Chemical process)
- 79815-20-6P
- 79854-38-9P
- 82834-16-0P (Perindopril) Role: PNU (Preparation
- 98167-06-7P Role: PUR (Purification or recovery)
- PEP (Phys
- SPN (Synthetic
- indolinecarboxylic acid resoln intermediate synthe
- synthesis of (2S)-indoline-2-carboxylic acid via r
Cite
CITATION STYLE
APA
Souvie, J.-C., & Lecouve, J.-P. (2003). Method for the synthesis of (2S)-indoline-2-carboxylic acid for use in the synthesis of perindopril. Eur. Pat. Appl. Retrieved from https://worldwide.espacenet.com/publicationDetails/biblio?CC=EP&NR=1354875A1&KC=A1&FT=D&ND=3&date=20031022&DB=EPODOC&locale=en_EP#
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