A synthetic and MO-SCF study of the trifluoroethoxylation of trifluoromethylchloropyridine derivatives

Abstract

The trifluoroethoxylation of a series of trifluoromethylchloropyridines was studied. The reactivity, selectivity and leaving ability of the chloro- and trifluoromethyl- group were discussed. The influence of different substituents on the reactivity of the pyridine ring was also studied using the molecular orbital method. © 1991.